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Principal Scientist - Molecular Biology
Job Posted: 2 days ago
Salary: £ Competitive
Job Type: Permanent
Location: Oxfordshire
Expire in: a month
Job Description
A pioneering early-stage biotechnology company, located in Oxfordshire, is seeking a Principal Scientist to join its growing Biology team. This innovative start-up is developing next-generation oligonucleotide-based therapeutics.
This is a rare opportunity to shape the scientific direction of a company from an early stage, contributing to both discovery and development of a novel class of drug candidates.
The Role
As Principal Scientist, you will lead the development and implementation of disease-relevant assays for the evaluation of novel oligonucleotide therapeutics. Working closely with the Head of Biology and external collaborators, you will play a critical role in translating early discoveries into preclinical proof-of-concept data.
Key responsibilities:
Lead development of assays to assess protein up-regulation in disease-relevant cell and animal models.
Execute and oversee molecular biology experiments (e.g. qPCR, luciferase assays, western blot, ELISA).
Collaborate with contract research organisations (CROs) and scientific advisors to advance discovery programmes.
Evaluate new disease indications and help shape strategic direction toward preclinical milestones.
Maintain rigorous experimental documentation and contribute to internal data presentations and planning.
About You
Required qualifications and experience:
PhD in molecular or cell biology, biochemistry, or related field with 7+ years of relevant experience (industry preferred).
Deep technical expertise in protein quantification (e.g. western blot, ELISA, capillary systems).
Strong background in mammalian cell culture, nucleic acid transfection, and gene expression analysis.
Proven experience designing or managing in vivo rodent studies through CROs.
Excellent communication, organisational and team-working skills.
Must be able to work on-site at Oxford's Old Road Campus.
Desirable:
Experience with oligonucleotide-based therapeutic platforms.
Background in indication finding and disease target assessment.
Ready to make an impact in an early-stage, high-potential biotech?
To apply, please send your CV in word format below or alternatively reach out to Rebecca Tilston @ Smart4ChemicalsBefore You Apply
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